Analgesic nephropathy: removal of phenacetin from proprietary analgesics.
نویسنده
چکیده
Since phenacetin was withdrawn from Askit Powders and Beecham's Powders in 1966 these preparations have declined in importance as a cause of analgesic nephropathy in Western Scotland. In most patients with analgesic nephropathy who persist in abuse of compound analgesics renal function continues to decline. The deterioration, however, is less rapid among those taking aspirin and caffeine mixtures than in those taking preparations which also contain phenacetin.
منابع مشابه
Paracetamol and analgesic nephropathy: Are you kidneying me?
INTRODUCTION Analgesic nephropathy is a disease resulting from the frequent use of combinations of analgesic medications over many years, leading to significant impairment of renal function. The observation of a large number of cases of renal failure in patients abusing analgesic mixtures containing phenacetin led to the initial recognition of the nephrotoxicity from the use of analgesics. Phen...
متن کاملTrends of analgesic nephropathy in two high-endemic regions with different legislation.
Analgesic abuse is related to a specific form of interstitial nephritis, but the exact nature of the causal agent remains controversial and this has resulted in differences in regulation. In Flanders, the free sale of phenacetin was banned, but the consumption of other combined analgesics remained free. In New South Wales, phenacetin was also banned, but 2 yr later the sales of all combined ana...
متن کاملNon-phenacetin analgesics and analgesic nephropathy
Background. A recent large-scale case-control study on analgesic nephropathy (SAN) [1] found no increased risk of end-stage renal disease (ESRD) in users of combined or single formulations of phenacetin-free analgesics. In a subgroup of 22 high users, however, a dose-dependent increased risk was found, which raised the question if these patients presented or not with analgesic nephropathy (AN)....
متن کاملAnalgesic nephropathy in the United Kingdom: Incidence, clinical features and pathogenesis.
Phenacetin came into use in 1887, just 10 years after the first case of renal papillary necrosis was reportedl 2 but the association between the excessive use of phenacetin-containing analgesics and the development of renal damage was not recognised until 1953,3 since when there has been gradual recognition that excessive analgesic consumption is a major cause of chronic renal disease in many p...
متن کاملIncidence of analgesic nephropathy in Berlin since 1983.
BACKGROUND Phenacetin was removed from the German market in 1986 and was replaced mainly in analgesic compounds by acetaminophen. Our objective was to examine the effect of this measure on the incidence of analgesic nephropathy in light of the changes in other end-stage renal diseases. METHODS We therefore compared the proportion of renal diseases in all patients starting dialysis treatment d...
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ورودعنوان ژورنال:
- British medical journal
دوره 4 5833 شماره
صفحات -
تاریخ انتشار 1972